GlutaredoxinV1, Main, Exploration, bibRecord, 000458

Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.

Identifieur interne : 000458 ( Main/Exploration ); précédent : 000457; suivant : 000459

Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.

Source :

Oncotarget [ 1949-2553 ] ; 2016.

RBID : pubmed:27203742

Descripteurs français

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Animals (MeSH), Carcinoma (metabolism), Carcinoma (pathology), Carrier Proteins (metabolism), Cell Movement (physiology), Epithelial-Mesenchymal Transition (physiology), ErbB Receptors (metabolism), Female (MeSH), Gene Expression Regulation, Neoplastic (physiology), Heterografts (MeSH), Humans (MeSH), Male (MeSH), Mice (MeSH), Mice, Nude (MeSH), Middle Aged (MeSH), Nasopharyngeal Carcinoma (MeSH), Nasopharyngeal Neoplasms (metabolism), Nasopharyngeal Neoplasms (pathology), Neoplasm Invasiveness (pathology), Proto-Oncogene Proteins c-akt (metabolism), Reactive Oxygen Species (MeSH), Signal Transduction (physiology).
MESH :
- chemical , metabolism : Carrier Proteins, ErbB Receptors, Proto-Oncogene Proteins c-akt.
- metabolism : Carcinoma, Nasopharyngeal Neoplasms.
- pathology : Carcinoma, Nasopharyngeal Neoplasms, Neoplasm Invasiveness.
- physiology : Cell Movement, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Signal Transduction.
- Adult, Aged, Animals, Female, Heterografts, Humans, Male, Mice, Mice, Nude, Middle Aged, Nasopharyngeal Carcinoma, Reactive Oxygen Species.

Abstract

Glutaredoxin 3 (GLRX3) is antioxidant enzyme, maintaining a low level of ROS, thus contributing to the survival and metastasis of several types of cancer. However, the expression and functions of GLRX3 have not been addressed in nasopharyngeal carcinoma (NPC). In this study, we found that GLRX3 was overexpressed in NPC. Knockdown of GLRX3 in NPC cell lines inhibited proliferation in vitro, tumorignesis in vivo, and colony formation. In addition, GLRX3 knockdown decreased the migration and invasion capacity of NPC cells by reversing the epithelial-mesenchymal transition (EMT). Furthermore, stabilization of GLRX3 was positively related to with epidermal growth factor receptor (EGFR) expression and negatively with ROS generation. Phosphorylation of Akt, a key downstream effector, was induced by EGFR signaling but did not rely on increasing ROS level in NPC cells. GLRX3 might be an oncoprotein in NPC, playing important roles in increasing redox reaction and activating EGFR/ Akt signals, so it may be a therapeutic target for NPC.

DOI: 10.18632/oncotarget.9454
PubMed: 27203742
PubMed Central: PMC5095054

Affiliations:

Japon, République populaire de Chine

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000437
to stream Main, to step Curation: 000437

Le document en format XML

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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Wei, Lili" sort="Wei, Lili" uniqKey="Wei L" first="Lili" last="Wei">Lili Wei</name>
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<author><name sortKey="Zhou, Xiaoying" sort="Zhou, Xiaoying" uniqKey="Zhou X" first="Xiaoying" last="Zhou">Xiaoying Zhou</name>
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<author><name sortKey="Chen, Yufeng" sort="Chen, Yufeng" uniqKey="Chen Y" first="Yufeng" last="Chen">Yufeng Chen</name>
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<author><name sortKey="Zheng, Shixing" sort="Zheng, Shixing" uniqKey="Zheng S" first="Shixing" last="Zheng">Shixing Zheng</name>
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<wicri:regionArea>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
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<author><name sortKey="Murata, Mariko" sort="Murata, Mariko" uniqKey="Murata M" first="Mariko" last="Murata">Mariko Murata</name>
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<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie</wicri:regionArea>
<wicri:noRegion>Mie</wicri:noRegion>
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<author><name sortKey="Huang, Guangwu" sort="Huang, Guangwu" uniqKey="Huang G" first="Guangwu" last="Huang">Guangwu Huang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
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<author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.</title>
<author><name sortKey="He, Feng" sort="He, Feng" uniqKey="He F" first="Feng" last="He">Feng He</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wei, Lili" sort="Wei, Lili" uniqKey="Wei L" first="Lili" last="Wei">Lili Wei</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luo, Wenqi" sort="Luo, Wenqi" uniqKey="Luo W" first="Wenqi" last="Luo">Wenqi Luo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
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<author><name sortKey="Li, Bo" sort="Li, Bo" uniqKey="Li B" first="Bo" last="Li">Bo Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Xiaoying" sort="Zhou, Xiaoying" uniqKey="Zhou X" first="Xiaoying" last="Zhou">Xiaoying Zhou</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiao, Xue" sort="Xiao, Xue" uniqKey="Xiao X" first="Xue" last="Xiao">Xue Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
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<author><name sortKey="You, Jingping" sort="You, Jingping" uniqKey="You J" first="Jingping" last="You">Jingping You</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yufeng" sort="Chen, Yufeng" uniqKey="Chen Y" first="Yufeng" last="Chen">Yufeng Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Shixing" sort="Zheng, Shixing" uniqKey="Zheng S" first="Shixing" last="Zheng">Shixing Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murata, Mariko" sort="Murata, Mariko" uniqKey="Murata M" first="Mariko" last="Murata">Mariko Murata</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie</wicri:regionArea>
<wicri:noRegion>Mie</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Guangwu" sort="Huang, Guangwu" uniqKey="Huang G" first="Guangwu" last="Huang">Guangwu Huang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Zhe" sort="Zhang, Zhe" uniqKey="Zhang Z" first="Zhe" last="Zhang">Zhe Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning</wicri:regionArea>
<wicri:noRegion>Nanning</wicri:noRegion>
</affiliation>
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<term>Aged (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Carcinoma (metabolism)</term>
<term>Carcinoma (pathology)</term>
<term>Carrier Proteins (metabolism)</term>
<term>Cell Movement (physiology)</term>
<term>Epithelial-Mesenchymal Transition (physiology)</term>
<term>ErbB Receptors (metabolism)</term>
<term>Female (MeSH)</term>
<term>Gene Expression Regulation, Neoplastic (physiology)</term>
<term>Heterografts (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Nude (MeSH)</term>
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<term>Neoplasm Invasiveness (pathology)</term>
<term>Proto-Oncogene Proteins c-akt (metabolism)</term>
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<term>Signal Transduction (physiology)</term>
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<term>Adulte d'âge moyen (MeSH)</term>
<term>Animaux (MeSH)</term>
<term>Cancer du nasopharynx (MeSH)</term>
<term>Carcinomes (anatomopathologie)</term>
<term>Carcinomes (métabolisme)</term>
<term>Espèces réactives de l'oxygène (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hétérogreffes (MeSH)</term>
<term>Invasion tumorale (anatomopathologie)</term>
<term>Mouvement cellulaire (physiologie)</term>
<term>Mâle (MeSH)</term>
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<term>Protéines proto-oncogènes c-akt (métabolisme)</term>
<term>Récepteurs ErbB (métabolisme)</term>
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<term>Souris nude (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
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<term>Transition épithélio-mésenchymateuse (physiologie)</term>
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<term>Tumeurs du rhinopharynx (métabolisme)</term>
</keywords>
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<term>ErbB Receptors</term>
<term>Proto-Oncogene Proteins c-akt</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinomes</term>
<term>Invasion tumorale</term>
<term>Tumeurs du rhinopharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma</term>
<term>Nasopharyngeal Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinomes</term>
<term>Protéines de transport</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Récepteurs ErbB</term>
<term>Tumeurs du rhinopharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma</term>
<term>Nasopharyngeal Neoplasms</term>
<term>Neoplasm Invasiveness</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Mouvement cellulaire</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Transduction du signal</term>
<term>Transition épithélio-mésenchymateuse</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Movement</term>
<term>Epithelial-Mesenchymal Transition</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Animals</term>
<term>Female</term>
<term>Heterografts</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Middle Aged</term>
<term>Nasopharyngeal Carcinoma</term>
<term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Animaux</term>
<term>Cancer du nasopharynx</term>
<term>Espèces réactives de l'oxygène</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hétérogreffes</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Sujet âgé</term>
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<front><div type="abstract" xml:lang="en">Glutaredoxin 3 (GLRX3) is antioxidant enzyme, maintaining a low level of ROS, thus contributing to the survival and metastasis of several types of cancer. However, the expression and functions of GLRX3 have not been addressed in nasopharyngeal carcinoma (NPC). In this study, we found that GLRX3 was overexpressed in NPC. Knockdown of GLRX3 in NPC cell lines inhibited proliferation in vitro, tumorignesis in vivo, and colony formation. In addition, GLRX3 knockdown decreased the migration and invasion capacity of NPC cells by reversing the epithelial-mesenchymal transition (EMT). Furthermore, stabilization of GLRX3 was positively related to with epidermal growth factor receptor (EGFR) expression and negatively with ROS generation. Phosphorylation of Akt, a key downstream effector, was induced by EGFR signaling but did not rely on increasing ROS level in NPC cells. GLRX3 might be an oncoprotein in NPC, playing important roles in increasing redox reaction and activating EGFR/ Akt signals, so it may be a therapeutic target for NPC.</div>
</front>
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<DateCompleted><Year>2018</Year>
<Month>01</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>02</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>7</Volume>
<Issue>24</Issue>
<PubDate><Year>2016</Year>
<Month>Jun</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>Oncotarget</Title>
<ISOAbbreviation>Oncotarget</ISOAbbreviation>
</Journal>
<ArticleTitle>Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.</ArticleTitle>
<Pagination><MedlinePgn>37000-37012</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.9454</ELocationID>
<Abstract><AbstractText>Glutaredoxin 3 (GLRX3) is antioxidant enzyme, maintaining a low level of ROS, thus contributing to the survival and metastasis of several types of cancer. However, the expression and functions of GLRX3 have not been addressed in nasopharyngeal carcinoma (NPC). In this study, we found that GLRX3 was overexpressed in NPC. Knockdown of GLRX3 in NPC cell lines inhibited proliferation in vitro, tumorignesis in vivo, and colony formation. In addition, GLRX3 knockdown decreased the migration and invasion capacity of NPC cells by reversing the epithelial-mesenchymal transition (EMT). Furthermore, stabilization of GLRX3 was positively related to with epidermal growth factor receptor (EGFR) expression and negatively with ROS generation. Phosphorylation of Akt, a key downstream effector, was induced by EGFR signaling but did not rely on increasing ROS level in NPC cells. GLRX3 might be an oncoprotein in NPC, playing important roles in increasing redox reaction and activating EGFR/ Akt signals, so it may be a therapeutic target for NPC.</AbstractText>
</Abstract>
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<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Lili</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Wenqi</ForeName>
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<AffiliationInfo><Affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
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<ForeName>Zhipeng</ForeName>
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<ForeName>Xiaoying</ForeName>
<Initials>X</Initials>
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<ForeName>Jingping</ForeName>
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<ForeName>Yufeng</ForeName>
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<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Shixing</ForeName>
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<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
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<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Murata</LastName>
<ForeName>Mariko</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, Japan.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Guangwu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Zhe</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.</Affiliation>
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<Language>eng</Language>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
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<MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064593" MajorTopicYN="N">Heterografts</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D000077274" MajorTopicYN="N">Nasopharyngeal Carcinoma</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
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<MeshHeading><DescriptorName UI="D009361" MajorTopicYN="N">Neoplasm Invasiveness</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Akt</Keyword>
<Keyword MajorTopicYN="N">EGFR</Keyword>
<Keyword MajorTopicYN="N">glutaredoxin 3</Keyword>
<Keyword MajorTopicYN="N">nasopharyngeal carcinoma</Keyword>
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<CoiStatement>The authors declare no conflicts of interest.</CoiStatement>
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<country name="Japon"><noRegion><name sortKey="Murata, Mariko" sort="Murata, Mariko" uniqKey="Murata M" first="Mariko" last="Murata">Mariko Murata</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/GlutaredoxinV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000458 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000458 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    GlutaredoxinV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:27203742
   |texte=   Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27203742" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GlutaredoxinV1

This area was generated with Dilib version V0.6.37.
Data generation: Wed Nov 18 15:13:42 2020. Site generation: Wed Nov 18 15:16:12 2020

	Serveur d'exploration sur la glutarédoxine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la glutarédoxine

Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.

Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.

Source :

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English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki